We would recommend dosing 1ml per week. Shake the bottle and dose 1ml into a cup full of tank water and dose it over a couple of hours in early in your lighting cycle.
While in most cases Nualgi alone works well, we have noticed some tanks working better with a combination of Nualgi and beneficial bacteria. If Nualgi alone does not show results after 2 weeks, in the 3rd week, we would recommend dosing BB 5 minutes after dosing Nualgi. The BB we have been using Microbelift Aquarium Balancer at recommended dosage in such tanks.